Annie’s Locker was started in 2008, inspired by a fellow runner who died from cancer and who, while battling cancer, asked for one thing: "Please run for me until I can run again." The idea was born to do something to inspire people toward a healthier lifestyle, and to remove barriers so that more people can find their "wings".

The very first depot in Oregon was a two-story building constructed in 1872. It was a frame structure with ticket office, passenger waiting room, and freight room on the first floor and crew sleeping quarters on the second floor. A fire was discovered at 5 am on Saturday, November 10, 1893, and an alarm was sounded and the fire bell was rung.